VASCULAR BIOLOGY EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2 –mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2
نویسندگان
چکیده
1Inserm Unité 940, Paris; 2Université Paris 7-Institut Universitaire d’Hematologie, Paris; 3Laboratory of Pharmacology, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris; 4Inserm Unité 553, Paris; 5Université Paris 12, Créteil; 6Centre National de la Recherche Scientifique-Unité Mixte de Recherche 7149, Laboratoire Croissance, Réparation et Régénération Tissulaires, Créteil; and 7Département de Dermatologie, Hôpital Saint Louis, Paris, France
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EMMPRIN Promotes Melanoma Cells Malignant Properties through a HIF-2alpha Mediated Up-Regulation of VEGF-Receptor-2
EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis. Here we demonstrate that EMMPRIN up-regulated VEGF receptor-2 (VEGFR-2) in two different primary melanoma cell lines and consequently increased migration and proliferation of these cells while inhibiting their apoptosis. SiRNA inhibition of VEGFR-2 expression abrogated these EMMPRIN effects. EMMPRIN regulat...
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تاریخ انتشار 2009